Nikita Chibrikov, Mason Appleton, Alex Iafallo, Gabe Vilardi, Kyle Connor and Vladislav Namestnikov scored the other Winnipeg goals.
Scheifele now has a 13-game point streak at home, totalling 20 points in that stretch.
David Pastrnak replied for the Bruins, who had a four-game winning streak snapped.
Connor Hellebuyck made 23 saves for Winnipeg (21-9-0)) at Canada Life Centre. Jeremy Swayman stopped 27 shots for Boston (15-12-3).
Iafallo, Connor and Vilardi put the game away with goals in the third period.
Scheifele scored his second goal of the game, one-timing a perfect setup from Josh Morrissey on a second-period power play, increasing the Winnipeg lead to 3-0.
Namestnikov had opened the scoring in the first period with Boston defenceman Brando Carlo off for four minutes after clipping Kyle Connor with a high stick. Namestnikov pounced on a loose puck in front of the net. With an assist on the goal, Pionk reached the 200-point mark since joining the Jets in a trade with the New York Rangers.
Connor later set up Scheifele for a one-timer, extending Scheifele’s point streak to five games.
Jets: Seemed sparked by the energy displayed by call-up Chibrikov. He drew an early penalty, started the play that led to Winnipeg’s first goal, then assisted on Iafallo’s power-play goal. Then, Scheifele took over, converting two great passes, and dominated play whenever he was on the ice. Chibrikov then scored late in the game.
Bruins: Were on their heels after the Jets took a 1-0 lead on the power play in the first period, but came to life in the second, scoring their first goal and missed a number of chances. Then they fell apart in the third.
Connor scored on a setup from Scheifele 1:25 into the third period giving Winnipeg a 4-1 lead and deflating the Bruins.
The Jets scored three power-play goals.
Bruins: Visit the Seattle Kraken on Thursday.
Jets: Host the Vegas Golden Knights on Thursday.